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SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.8
USERS' SCORE
Good
Based on 1 Reviews
8.5
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Zinc(from 270 mg Zinc Picolinate)
50 mg
455%
Top Medical Research Studies
8
Zinc enhances blood clot formation
Enhanced coagulation cascade activation and styptic effects of Zn@SiO nanocomposite.
Study validates zinc's hemostatic effects
We explored how zinc affects blood clotting, particularly through a substance called Zn@SiO nanocomposite. This material shows promise as a hemostatic agent, which means it helps stop bleeding by promoting the formation of stable blood clots.
During our analysis, we examined various aspects of how this nanocomposite interacts with blood. It activates specific factors in the coagulation cascade—the process our bodies use to form clots. With the presence of zinc in the material, we observed enhanced activation of these factors, leading to improved clot formation.
Our research involved synthesizing and characterizing the Zn@SiO nanocomposite using several methods, including XRD, FTIR, and HRTEM. We also tested its effects on red blood cell aggregation, platelet adhesion, and several vital clotting time measures. The results indicate that Zn@SiO has significant hemostatic properties, showing potential for use in surgeries and trauma care.
This study highlights the exciting role of zinc in optimizing hemostasis, making it a candidate worth considering for medical applications related to bleeding management.
During our analysis, we examined various aspects of how this nanocomposite interacts with blood. It activates specific factors in the coagulation cascade—the process our bodies use to form clots. With the presence of zinc in the material, we observed enhanced activation of these factors, leading to improved clot formation.
Our research involved synthesizing and characterizing the Zn@SiO nanocomposite using several methods, including XRD, FTIR, and HRTEM. We also tested its effects on red blood cell aggregation, platelet adhesion, and several vital clotting time measures. The results indicate that Zn@SiO has significant hemostatic properties, showing potential for use in surgeries and trauma care.
This study highlights the exciting role of zinc in optimizing hemostasis, making it a candidate worth considering for medical applications related to bleeding management.
Read More
8
Zinc enhances rutin's anti-thrombotic effects
Enhanced inhibition of protein disulfide isomerase and anti-thrombotic activity of a rutin derivative: rutin:Zn complex.
High relevance to clotting analysis
We observed a significant advance in our understanding of how zinc therapy can affect blood clotting, particularly with a compound called rutin. This study explored how zinc ions can be combined with rutin to enhance its aqueous solubility and therapeutic potential.
Rutin, a natural flavonoid found in various plants and foods, has been known for its ability to inhibit a protein called protein disulfide isomerase (PDI), which plays a role in blood clotting. However, we encountered challenges with rutin’s low solubility in water, which limits its effectiveness in therapeutic settings.
In this study, we found that when we chelated zinc ions with rutin, the resulting rutin:Zn complex showed a remarkable fourfold increase in solubility. More excitingly, this complex also exhibited a stronger inhibition of PDI activity compared to rutin alone.
In further testing with a murine model designed to induce arterial thrombosis, the rutin:Zn complex demonstrated a notable ability to slow down arterial occlusion without increasing bleeding risks. This suggests that zinc not only aids in solubility but also enhances the anti-thrombotic properties of rutin.
Overall, our findings indicate that combining zinc with certain flavonoids could be a promising strategy for elevating their benefits in combating blood clots.
Rutin, a natural flavonoid found in various plants and foods, has been known for its ability to inhibit a protein called protein disulfide isomerase (PDI), which plays a role in blood clotting. However, we encountered challenges with rutin’s low solubility in water, which limits its effectiveness in therapeutic settings.
In this study, we found that when we chelated zinc ions with rutin, the resulting rutin:Zn complex showed a remarkable fourfold increase in solubility. More excitingly, this complex also exhibited a stronger inhibition of PDI activity compared to rutin alone.
In further testing with a murine model designed to induce arterial thrombosis, the rutin:Zn complex demonstrated a notable ability to slow down arterial occlusion without increasing bleeding risks. This suggests that zinc not only aids in solubility but also enhances the anti-thrombotic properties of rutin.
Overall, our findings indicate that combining zinc with certain flavonoids could be a promising strategy for elevating their benefits in combating blood clots.
Read More
9.5
Zinc enhances enzyme activity minimally
Least hemolytic, 12.6 kDa, plasmin-like fibrinolytic protease from marine Penicillium steckii KU1.
Relevance score indicates partial significance
We explored the effects of a newly discovered fibrinolytic enzyme from the marine fungus Penicillium steckii KU1, particularly its interaction with zinc in the context of blood clot dissolution. This enzyme, which has a molecular weight of 12.6 kDa, is a plasmin-like protein that becomes more active in the presence of zinc. While it effectively dissolves blood clots, achieving complete dissolution in just 30 minutes with a specific concentration, we also observed that its activity is significantly inhibited by certain agents like EDTA.
Interestingly, the enzyme demonstrated a low level of hemolysis at just 2.60%, indicating that it could be a safer alternative for thrombolytic therapy. However, it's important to note that while zinc enhances the enzymatic activity, the isolated effects of zinc on blood clot breakdown remain somewhat unclear due to the enzyme's overall presence.
This research highlights the potential of the marine-derived enzyme and the role of zinc, suggesting that further studies could provide deeper insights into improving thrombolytic treatments. These findings could be significant for enhancing the safety and effectiveness of therapies designed for clot management.
Interestingly, the enzyme demonstrated a low level of hemolysis at just 2.60%, indicating that it could be a safer alternative for thrombolytic therapy. However, it's important to note that while zinc enhances the enzymatic activity, the isolated effects of zinc on blood clot breakdown remain somewhat unclear due to the enzyme's overall presence.
This research highlights the potential of the marine-derived enzyme and the role of zinc, suggesting that further studies could provide deeper insights into improving thrombolytic treatments. These findings could be significant for enhancing the safety and effectiveness of therapies designed for clot management.
Read More
Most Useful Reviews
8.3
Immunostimulating effects
I take zinc as advised by my endocrinologist to support my thyroid alongside iodine and selenium. For the past three years, I have taken zinc for three months and then taken a break for 1.5 months. It is well tolerated, with no negative side effects. Since starting these supplements, herpes occurrences have significantly decreased, and I experience fewer colds. If I feel unwell, I increase my zinc intake for a few days, which helps prevent illness. I recommend this product but advise consulting a doctor or testing for blood clot levels.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.8
9.5
Zinc enhances enzyme activity minimally
Least hemolytic, 12.6 kDa, plasmin-like fibrinolytic protease from marine Penicillium steckii KU1.
Relevance score indicates partial significance
We explored the effects of a newly discovered fibrinolytic enzyme from the marine fungus Penicillium steckii KU1, particularly its interaction with zinc in the context of blood clot dissolution. This enzyme, which has a molecular weight of 12.6 kDa, is a plasmin-like protein that becomes more active in the presence of zinc. While it effectively dissolves blood clots, achieving complete dissolution in just 30 minutes with a specific concentration, we also observed that its activity is significantly inhibited by certain agents like EDTA.
Interestingly, the enzyme demonstrated a low level of hemolysis at just 2.60%, indicating that it could be a safer alternative for thrombolytic therapy. However, it's important to note that while zinc enhances the enzymatic activity, the isolated effects of zinc on blood clot breakdown remain somewhat unclear due to the enzyme's overall presence.
This research highlights the potential of the marine-derived enzyme and the role of zinc, suggesting that further studies could provide deeper insights into improving thrombolytic treatments. These findings could be significant for enhancing the safety and effectiveness of therapies designed for clot management.
Interestingly, the enzyme demonstrated a low level of hemolysis at just 2.60%, indicating that it could be a safer alternative for thrombolytic therapy. However, it's important to note that while zinc enhances the enzymatic activity, the isolated effects of zinc on blood clot breakdown remain somewhat unclear due to the enzyme's overall presence.
This research highlights the potential of the marine-derived enzyme and the role of zinc, suggesting that further studies could provide deeper insights into improving thrombolytic treatments. These findings could be significant for enhancing the safety and effectiveness of therapies designed for clot management.
Read More
9.5
Zinc benefits blood clot healing
A new hemostatic agent composed of Zn-enriched Ca alginate activates vascular endothelial cells and promotes tissue repair .
Highlights zinc's role in healing
We investigated how a new hemostatic agent, HEMO-IONIC®, which is enriched with zinc and made from calcium alginate, influences blood clotting and tissue repair. Our focus was on how this innovative compress can help control bleeding while also promoting healing after surgery.
In our study, we compared the effects of HEMO-IONIC with other common hemostatic products, like Surgicel® and TachoSil®. What we found was impressive: HEMO-IONIC not only effectively helped to achieve hemostasis, but it also supported the health of vascular endothelial cells, which are crucial for tissue repair.
Unlike Surgicel, which showed high cytotoxicity, and TachoSil, which inhibited cell migration, HEMO-IONIC promoted the migration of endothelial cells and increased angiogenesis—the formation of new blood vessels. This means that it not only helps stop bleeding but also enhances the body's natural repair processes by attracting essential healing cells and speeding up the maturation of the extracellular matrix.
Overall, we found that using HEMO-IONIC at the end of surgical procedures has long-term positive effects on every phase of tissue repair, making it a promising alternative to traditional hemostatic agents.
In our study, we compared the effects of HEMO-IONIC with other common hemostatic products, like Surgicel® and TachoSil®. What we found was impressive: HEMO-IONIC not only effectively helped to achieve hemostasis, but it also supported the health of vascular endothelial cells, which are crucial for tissue repair.
Unlike Surgicel, which showed high cytotoxicity, and TachoSil, which inhibited cell migration, HEMO-IONIC promoted the migration of endothelial cells and increased angiogenesis—the formation of new blood vessels. This means that it not only helps stop bleeding but also enhances the body's natural repair processes by attracting essential healing cells and speeding up the maturation of the extracellular matrix.
Overall, we found that using HEMO-IONIC at the end of surgical procedures has long-term positive effects on every phase of tissue repair, making it a promising alternative to traditional hemostatic agents.
Read More
8
Zinc enhances blood clot formation
Enhanced coagulation cascade activation and styptic effects of Zn@SiO nanocomposite.
Study validates zinc's hemostatic effects
We explored how zinc affects blood clotting, particularly through a substance called Zn@SiO nanocomposite. This material shows promise as a hemostatic agent, which means it helps stop bleeding by promoting the formation of stable blood clots.
During our analysis, we examined various aspects of how this nanocomposite interacts with blood. It activates specific factors in the coagulation cascade—the process our bodies use to form clots. With the presence of zinc in the material, we observed enhanced activation of these factors, leading to improved clot formation.
Our research involved synthesizing and characterizing the Zn@SiO nanocomposite using several methods, including XRD, FTIR, and HRTEM. We also tested its effects on red blood cell aggregation, platelet adhesion, and several vital clotting time measures. The results indicate that Zn@SiO has significant hemostatic properties, showing potential for use in surgeries and trauma care.
This study highlights the exciting role of zinc in optimizing hemostasis, making it a candidate worth considering for medical applications related to bleeding management.
During our analysis, we examined various aspects of how this nanocomposite interacts with blood. It activates specific factors in the coagulation cascade—the process our bodies use to form clots. With the presence of zinc in the material, we observed enhanced activation of these factors, leading to improved clot formation.
Our research involved synthesizing and characterizing the Zn@SiO nanocomposite using several methods, including XRD, FTIR, and HRTEM. We also tested its effects on red blood cell aggregation, platelet adhesion, and several vital clotting time measures. The results indicate that Zn@SiO has significant hemostatic properties, showing potential for use in surgeries and trauma care.
This study highlights the exciting role of zinc in optimizing hemostasis, making it a candidate worth considering for medical applications related to bleeding management.
Read More
8
Zinc enhances PGI signaling efficiency
Platelet zinc status regulates prostaglandin-induced signaling, altering thrombus formation.
Highly relevant to clotting mechanisms
We examined how zinc (Zn) impacts blood clotting, particularly focusing on its interaction with prostacyclin (PGI) signaling in platelets. The study revealed that about 17.3% of people worldwide experience some level of zinc deficiency, which can lead to impaired blood clotting and increased bleeding.
By conducting a series of experiments involving platelet aggregation and thrombus formation, we found that zinc chelators, which bind and remove zinc, enhanced the signaling pathway of PGI. This signaling is crucial because it helps platelets avoid becoming overly activated, thus reducing clot formation.
Interestingly, we observed that the presence of these zinc chelators resulted in either the breakdown of preformed clots in whole blood or the reversal of platelet spreading in isolated platelets. Moreover, our findings indicated that blocking adenylyl cyclase—an enzyme involved in PGI signaling—prevented the effects of zinc chelation, solidifying the idea that zinc plays a regulatory role in this process.
Ultimately, our research suggests that reducing zinc levels can amplify the effectiveness of PGI in controlling platelet activity and preventing excessive clotting. This could have important implications for individuals suffering from bleeding disorders or those at risk of blood clot-related complications.
By conducting a series of experiments involving platelet aggregation and thrombus formation, we found that zinc chelators, which bind and remove zinc, enhanced the signaling pathway of PGI. This signaling is crucial because it helps platelets avoid becoming overly activated, thus reducing clot formation.
Interestingly, we observed that the presence of these zinc chelators resulted in either the breakdown of preformed clots in whole blood or the reversal of platelet spreading in isolated platelets. Moreover, our findings indicated that blocking adenylyl cyclase—an enzyme involved in PGI signaling—prevented the effects of zinc chelation, solidifying the idea that zinc plays a regulatory role in this process.
Ultimately, our research suggests that reducing zinc levels can amplify the effectiveness of PGI in controlling platelet activity and preventing excessive clotting. This could have important implications for individuals suffering from bleeding disorders or those at risk of blood clot-related complications.
Read More
8
Zinc enhances rutin's anti-thrombotic effects
Enhanced inhibition of protein disulfide isomerase and anti-thrombotic activity of a rutin derivative: rutin:Zn complex.
High relevance to clotting analysis
We observed a significant advance in our understanding of how zinc therapy can affect blood clotting, particularly with a compound called rutin. This study explored how zinc ions can be combined with rutin to enhance its aqueous solubility and therapeutic potential.
Rutin, a natural flavonoid found in various plants and foods, has been known for its ability to inhibit a protein called protein disulfide isomerase (PDI), which plays a role in blood clotting. However, we encountered challenges with rutin’s low solubility in water, which limits its effectiveness in therapeutic settings.
In this study, we found that when we chelated zinc ions with rutin, the resulting rutin:Zn complex showed a remarkable fourfold increase in solubility. More excitingly, this complex also exhibited a stronger inhibition of PDI activity compared to rutin alone.
In further testing with a murine model designed to induce arterial thrombosis, the rutin:Zn complex demonstrated a notable ability to slow down arterial occlusion without increasing bleeding risks. This suggests that zinc not only aids in solubility but also enhances the anti-thrombotic properties of rutin.
Overall, our findings indicate that combining zinc with certain flavonoids could be a promising strategy for elevating their benefits in combating blood clots.
Rutin, a natural flavonoid found in various plants and foods, has been known for its ability to inhibit a protein called protein disulfide isomerase (PDI), which plays a role in blood clotting. However, we encountered challenges with rutin’s low solubility in water, which limits its effectiveness in therapeutic settings.
In this study, we found that when we chelated zinc ions with rutin, the resulting rutin:Zn complex showed a remarkable fourfold increase in solubility. More excitingly, this complex also exhibited a stronger inhibition of PDI activity compared to rutin alone.
In further testing with a murine model designed to induce arterial thrombosis, the rutin:Zn complex demonstrated a notable ability to slow down arterial occlusion without increasing bleeding risks. This suggests that zinc not only aids in solubility but also enhances the anti-thrombotic properties of rutin.
Overall, our findings indicate that combining zinc with certain flavonoids could be a promising strategy for elevating their benefits in combating blood clots.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Reviews
8.5
8.3
Immunostimulating effects
I take zinc as advised by my endocrinologist to support my thyroid alongside iodine and selenium. For the past three years, I have taken zinc for three months and then taken a break for 1.5 months. It is well tolerated, with no negative side effects. Since starting these supplements, herpes occurrences have significantly decreased, and I experience fewer colds. If I feel unwell, I increase my zinc intake for a few days, which helps prevent illness. I recommend this product but advise consulting a doctor or testing for blood clot levels.
Read More
